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In erastin- or RSL3-induced ferroptosis in hepatocellular carcinoma cells, IFN- triggers the JAK-STAT-IRF1 axis and inhibits transcription of the System Xc subunits SLC3A2 and SLC7A11 ( 4.2.2 Other key signaling pathways NF-KB signaling lies at the nexus of many inflammatory cytokines and immune receptors, thus exerting bidirectional effects on ferroptosis

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