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Key Biosensor Platforms roGFP2-Grx1: This widely used biosensor consists of a redox-sensitive green fluorescent protein (roGFP2) fused to human glutaredoxin-1 (Grx1)

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In addition to the possibility of applying the c-Glue concept to new small-molecule degraders, the structural similarity to CRBN suggests that YPEL5 could be amenable to an MGD discovery strategy analogous to what has been done for IMiDs