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For example, LPA initiates signaling pathways or exerts biological effects through different receptor subtypes, promotes cell growth and differentiation through LPA receptors 1, 3, and PPAR-, and contributes to mast cell proliferation during inflammation

H.BennerC.LeblancM.et al (2015)

In addition to mutated genes, NMD modulates the expression of normal transcripts that support tumor progression, including mRNAs encoding stress-response factors, signaling proteins, and noncoding RNAs that support tumorigenic phenotypes

Intriguingly, our data may also explain spontaneous neuroblastoma regression, the mechanisms of which have remained elusive