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Oncologist 27(8):663-674, 2022

USA 117 , 2879528805 (2020)

doi: 10.3168/jds.2015-10157 93 OsorioJ

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation