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Lia Brann, Oakland

NAMPT-driven NAD + salvage pathway is critical for maintaining NAD + levels in skeletal muscles

doi: 10.1016/j.repc.2017.07.003 42

found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

ahin, M.S

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