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Helper or cytotoxic T cells secrete factors such as interferon- (IFN-) and IL-17 that compromise cartilage integrity ( Although dendritic cells (DCs) and natural killer (NK) cells are less abundant in OA synovium compared with macrophages and T cells, they can still influence synovitis severity and iron homeostasis by secreting inflammatory mediators or cooperating with T cells

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Although etomoxir diminished ER stress signaling, it did not block it entirely

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