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Meanwhile, ATP detection assays confirmed that the ATP level in GGCT-knockdown cells was significantly reduced and rescued in sodium pyruvate or JX06 treatment groups (Fig

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Activation of endogenous antioxidants: the core antioxidant system The Kelchlike ECHassociated protein 1 (Keap1)nuclear factor erythroid 2related factor 2 (Nrf2)antioxidant response element (ARE) pathway is the center of the biological response to oxidative stress, regulating a variety of cell-protecting proteins (also known as phase 2 enzymes) to maintain the homeostasis of ROS levels in cells [98,99,100,101,102]