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Upon recognition by nuclear receptor coactivator 4, intracellular ferritin is autophagocytosed and degraded by lysosomes to release free iron and generate ROS through the iron-dependent Fenton reaction or activate lipoxygenase to promote lipid peroxidation and promote ferroptosis

The fraction of epithelial cells was higher in CyTOF than CITE-seq, likely because dead cell depletion was not needed prior to the CyTOF analysis

Factors such as hormones and nutrition can influence this phases length

Nrf2 regulates the arginase 1(+) microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice