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Additionally, inflammatory cytokines such as TNF- and IL-6 activate JNK and IKK kinases, further promoting IRS-1 serine phosphorylation and creating a vicious cycle that perpetuates insulin signaling dysfunction (57)

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Instead of a sand bed to hide the reward, as is the case with the food reward dry maze, the Oasis Maze has small hidden wells, scattered around the arena, holding water