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If you are pregnant or breastfeeding, the precautionary position is to defer microinfusion until the postpartum period and consultation with your obstetrician

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Notably, restoration of SIRT1 rescues cells from ferroptotic cell death, supporting the critical role of SIRT1 in SYNCRIP-mediated ferroptosis resistance

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To map the region of the human PPARGC1A promoter that is responsible for the inhibitory effect of PPAR on PPAR-mediated upregulation of PPARGC1A expression, we generated a panel of PPARGC1A promoter deletion mutants (Supplemental Figure 4C) and cloned this panel into the pGL3-BV luciferase reporter plasmid