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Additional cases of ILD/pneumonitis have been observed in the postmarketing setting, with fatalities reported [see Adverse Reactions (6.2)]

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PMID 14499682

Also, unlike large, protein-based biologics, these small molecule drugs are less likely to provoke immune reactions (Bagel 2014

Directly determining the binding affinities of inhibitors using isothermal titration calorimetry and surface plasmon resonance is too costly