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The parallel increases in oxidative stress markers (MDA) and inflammatory mediators (NFB) observed in our study may create a self-amplifying cycle that sustains caspase-3 activation, as suggested by Almarzouq &Al-Maghrebi 62 , Arena, Iacona 63

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These results suggest that similar metabolic alterations occur in murine and human kidneys with TLS and that urinary GSH could be a noninvasive diagnostic biomarker to detect TLS in the kidney

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