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G6PD deficiency which reduces NADPH production phenocopies GSR impairment for exactly this reason: less NADPH means less GSR-driven GSSG reduction, less available GSH, and more oxidative stress under equivalent ROS production

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(2020) The antiaging activity of ergothioneine in UVA-irradiated human dermal fibroblasts via the inhibition of the AP-1 pathway and the activation of Nrf2-mediated antioxidant genes

Similarly, TME-responsive nanoplatforms utilize stimuli like hypoxia, redox imbalance, and enzymatic activity to achieve precise drug release [78]

These data were approved by Raheem et al

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