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Therefore, we conducted this study to compare the safety and efficacy of proactive and reactive DDAVP strategies, in conjunction with 3%NaCl, for treating severe symptomatic hyponatremia

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Additionally, several factors can distort the interpretation of sex differences in drug metabolism, including genetic polymorphisms affecting enzymes like UGT, TPMT, and COMT, hormonal fluctuations, age-related changes, underlying health conditions, co-medication, and variations in study design (e.g., unbalanced sex ratios, inconsistent dosing strategies

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Bacterial functions were represented by MetaCyc pathways [75] or enzyme commission (EC) numbers