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Ice packs and an analgesic may be used, if required, to ease the discomfort

I found this technique on my saline bottle's insert and it supposedly helps the saline solution get into all the nasal cavities

doi: 10.1098/rstb.2013.0227

Disclosures: Yayun Ren: HistoIndex Pte Ltd: Employee, Dean Tai: Histoindex.com: Employee, Elaine Chng: Nothing to Disclose, Kutbuddin Akbary: HistoIndex Pte Ltd: Employee, Nikolai Naoumov: Nothing to Disclose, Jonathan Fallowfield: Stimuliver: Advisor, Ipsen: Advisor, Kynos Therapeutics: Advisor, Resolution Therapeutics: Consultant, River 2 Renal Corp.: Advisor, Global Clinical Trial Partners: Advisor, Guidepoint: Consultant, GlaxoSmithKline: Grant/Research Support, Genentech: Grant/Research Support, Intercept Pharmaceuticals: Grant/Research Support, Timothy Kendall: Nothing to Disclose, David Kleiner: Nothing to Disclose, Arun Sanyal: Genfit, Akarna, Tiziana, Durect, Inversago, Hemoshear, North: Stock - publicly traded company, Astra Zeneca ( 60K), Boston Pharmaceutical ( 2) in efforts to improve clinical outcomes and prevent cirrhosis by performing early intervention

All other authors have no conflicts of interest to declare

Targeted glucose or glutamine metabolic therapy combined with PD-1/PD-L1 checkpoint blockade immunotherapy for the treatment of tumors: mechanisms and strategies