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Typical 2-Cys Prxs (i.e., human Prx 1-4) feature a resolving cysteine at the C-terminus and form intermolecular disulfides between adjacent subunits, while atypical 2-Cys Prxs (i.e., human Prx5) form intramolecular disulfides

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These serological abnormalities are not isolated findings but are connected to broader physiological disruptions, including liver function, which is crucial in iron metabolism (209)

Advanced/Metastatic CRC - Targeted Therapies in CRC

10.3390/antiox11061131 100

[76] The presence of such metals in biological systems in an uncomplexed form (not in a protein or other protective metal complex) can significantly increase the level of oxidative stress