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Conclusions In CKD, OS has emerged as a novel disease-related risk factor for CV disease, mortality, and progression to ESRD

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Buyers in those categories should apply the product-by-product verification approach described in Section 8

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Taking into account that superoxide is effectively removed from the reaction (see Mitochondrial ROS detoxifying systems below) and the possibility of highly reduced state of many redox carriers (see discussion under ROS production at Complex I), the reaction becomes virtually irreversible