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MHR Basic Sci Reprod Med 20(10):948959 Los M, Craen MVd, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Drge W, Krammer PH, Fiers W, Schulze-Osthoff K (1995) Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

Similarly, this is also seen in the setting of many chronic diseases such as metabolic syndrome and diabetes [3,4], atherosclerosis and cardiovascular disease [5], chronic kidney disease [6], neurodegenerative conditions such as Alzheimers disease and Parkinsons disease [7-9], as well as autoimmune diseases [10], cancer [11] and chronic infections such as human immunodeficiency virus [12]

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Yet, it is unknown if this formulation would exert primarily local effects on the digestive system, or if it would work systemically

Schuurman M, et al

10.1016/j.jep.2015.02.017 126 TangF.ZhangJ