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ACHIEVE-1 (NCT05971940) This trial evaluated orforglipron as monotherapy or add-on to metformin in adults with early type 2 diabetes

Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia