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10.3389/fonc.2022.829524 Front Oncol

The therapeutic market worldwide is projected to reach US$33.96 billion by 2025 3

A defect in collagen polymerization was reported in homocystinuric patients with severe hyperhomocysteinemia (Lubec et al, 1996a)

This metabolic stability contrasts sharply with full-length growth hormone, which can cause glucose intolerance, elevated blood sugar, and insulin resistance (diabetogenic effects)

Patients with diabetic kidney disease (DKD) exhibit pronounced gut microbiota dysbiosis, characterized by decreased abundance of commensal bacteria and increased prevalence of uremic toxin-producing bacteria (98) demonstrated that Roseburia intestinalis was significantly decreased while Bacteroides stercoris was markedly increased in the gut of biopsy-proven diabetic nephropathy patients, and this dysbiosis was closely correlated with parameters of lipid metabolism, glucose metabolism, and renal function

Bartels, S