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In addition, doses equal to or greater than 140 mg/kg/day (about 34 times a daily oral human dose of 40 mg on a body surface area basis), produced treatment-related decreases in body weight (approximately 14%) and body weight gain, decreases in femur weight and femur length, and affected overall growth

Diabetes Care 42(6):10341041

Reusable pens (with replaceable cartridges) may have higher initial costs but lower long-term costs for high-volume settings like clinics

But the real answer depends on several factors that make a significant difference in whether your vial is still good at week four, week eight, or week twelve