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While pharmacological inhibition of HDACs has generally been associated with enhanced cognitive function [6, 127], our results reveal a distinct, isoform-specific role for HDAC9: neuronal overexpression of HDAC9 preserves cognitive function during aging and mitigates AD-associated cognitive deficits and neuropathology

Blood, 112 (6), 22142221

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Conversely, some studies show that a deficiency in vitamin B12 may cause appetite loss, potentially leading to weight loss if left untreated ( If youre low or deficient in B12, your healthcare provider will likely recommend oral vitamin B12 supplements or injections to increase your blood levels ( summary Low levels of vitamin B12 can cause megaloblastic anemia, which is characterized by shortness of breath, headaches, and fatigue

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