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Loss of heterozygosity of the NF1 gene in Schwann cells has been shown to be the necessary event for the development of discrete neurofibromas.8 Furthermore, neurofibromin-deficient Schwann cells secrete a substance which stimulates mast cell migration which, in turn, stimulates production of extracellular matrix and angiogenesis.9 Astrocytes lacking NF1 expression cannot form optic nerve gliomas on their own

In the validation stage, an independent cohort (Cohort 2) comprising four age- and sex-matched groups (30 RBD-PD patients, 14 non-RBD-PD patients, 30 iRBD patients and 30 Ctrl subjects, all of whom underwent gold-standard video polysomnography (vPSG) assessment for the confirmation of RBD status) was included

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Clin Pharmacokinet 63 , 10891109 (2024)

Figure 5 5.5 Application in skin and hair health The skin, the bodys largest organ, acts as a dynamic interface with the environment, playing essential roles in protection against UV radiation, pathogens, and extreme temperatures (390, 391)

doi: 10.1080/19490976.2019.1700754 18 van der HouwenTBvan LaarJAMKappenJHvan HagenPMde ZoeteMRvan MuijlwijkGHet al