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The mature IGF-IR is a heterotetramer with two chains and two chains [23]

Patients with chronic stubborn midsection adiposity that has been resistant to conventional weight-loss approaches

doi: 10.1016/S0278-5846(03)00023-X 198 VillarroelM

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Interestingly, the increases in MEK1/2 and p70S6K1 phosphorylation were also observed when cells were subjected to the treatment of AKT inhibitor or genetic knockdown of AKT2 but not AKT1, suggesting that AKT2 inhibition stimulates MEK1/2 phosphorylation to activate p70S6K1

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