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The surface of this hybrid system is coated with polyoxometalates and polyethylene glycol, which enhances cellular internalization via passive diffusion and effectively inhibits A aggregation[135] (Fig

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Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state

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In the CVB3-CP17 structure, CP17 sits upright in the interprotomer pocket due to stacking interactions against Phe76 of VP1 and Phe236 of VP3 from CVB3 29

Abbreviations 5-HD: 5-hydroxydecanoate AMPK: AMP-activated protein kinase ETC: Electron transport chain G-6-P: Glucose-6-phosphate Glut-1: Glucose transporter 1 LPS: Lipopolysaccharide MnSOD: Manganese superoxide dismutase MRS: magnetic resonance spectrum mtDNA: Mitochondrial DNA nDNA: Nuclear DNA NO: nitric oxide NOS: nitrogen species NRF-1: Nuclear respiratory factor-1 NRF-1/2: nuclear respiratory factors 1 and 2 OXPHOS: Oxidative phosphorylation PGC-1: PRAR-coactivator-1 PMN: Polymorphonuclear neutrophil rhTFAM: Recombinant human TFAM ROS: Reactive oxygen species TFAM: Mitochondrial transcription factor A TPP: Triphenylphosphonium VDACs: Voltage dependent anion channels References Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al