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429,430,431,432,433 The mechanism of enhanced glycolysis involves the activation of pyruvate kinase isoenzyme M2 (PKM2), which triggers downstream inflammatory factors in a hypoxia-inducible factor 1 (HIF-1)-dependent manner

5,8 Results of one trial suggested that intranasal platelet-rich plasma improved patients ability to discriminate smells to some extent, but there was no significant change in subjective smell scores compared with baseline, limiting its potential as a definitive treatment

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However, neurons are unable to degrade the vesicles containing neuromelanin, leading to its accumulation throughout life