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Benoist 2011, PMID 21719467, which studied Nle1-AngIV analogs rather than Dihexa itself)

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Its compact tetrapeptide structure makes it especially relevant in studies focused on cellular communication and age-associated biological response

doi: 10.3389/fimmu.2020.01741 91 RothhammerVMascanfroniIDBunseLTakenakaMCKenisonJEMayoLet al

Although this shortened poly(A) tail is unable to allow mRNA to associate with PABP or initiation factor eIF4E, preventing mRNA expression, the shortened tail associates with exoribonuclease 1 (XRN1), exoribonuclease RRP6, Dcp1p, Dcp2p and/or the cytoplasmic Lsm1p-7p followed by de-capping and subsequent degradation [64]

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