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DS patients have a higher risk of developing dementia similar to Alzheimer's disease (AD), with amyloid plaques and neurofibrillary tangles

It should be noted that the effect of B12 was pleiotropic, that is, it regulates several metabolic or intracellular signaling pathways maladjusted by COVID-19 despite the glucocorticoid treatment that patients received during hospitalization

doi: 10.3390/antiox10081316 3 AbuaishS.Al-OtaibiN

ColomboGClericiMGiustariniDPortinaroNBadalamentiSRossiRet alA central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (Aopp) formation

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doi: 10.3892/ijo.2021.5275, 23