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To date, most models rely on commercial ECs such as HUVECs due to their availability and ease of use (145, 196)

Epithalon commonly stacks with MOTS-c (mitochondrial), NAD+ (cellular coenzyme), or CJC-1295/Ipamorelin (growth peptides) for comprehensive longevity protocols

Among significantly upregulated genes (Dataset EV1) we found known factors upregulated by brain injury such as the JNK target mmp1 and several GO terms related to redox-dependent processes (Fig EV1A)

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