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Mass-spectrometry-based histidine plasma levels determined at baseline according to frequency of meals per week including each food item (Supplementary Table 1g)

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After optimizing the ionization and detection conditions, good results were obtained using DBSs with the ultra-performance convergence chromatography quadrupole-time-of-flight (UPC 2 -QTOF), making this method suitable for clinical analysis of lipid plasma samples in large-scale studies