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PMID: 39741309 J Transl MedUSP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1

For example, DNA strand breaks and reversible cross-links with DNA or histone proteins of nucleosome core particles from AP sites affect transcription and replication in cells, further inducing gene mutations, which may cause apoptosis or cell carcinogenesis [19, 20]

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Thus, there is still a good deal to learn regarding the identity of the actual physiological activators of glutaminases, particularly the structural changes induced by these activators necessary to achieve catalysis

Chen JF, Liu H, Ni HF, Lv LL, Zhang MH, Zhang AH, Tang RN, Chen PS, Liu BC