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de Moraes MeineBFranceschiTSBonaNPSpohrLPedraNSSpanevelloRMet alChemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver

Between 7 and 33.7% of fulminant hepatitis cases stem from HBV infection (Ichai 2011)

Under physiological conditions, mitochondria localized near the apical membrane form a buffering zone that restricts the spread of Ca 2+ signals from the subplasmalemmal region to the cell interior, thereby protecting PACs from Ca 2+ -induced injury ( 2+ microdomains arising at close contact between the PM and mitochondria enable rapid mitochondrial Ca 2+ uptake, activation of TCA cycle enzymes, and stimulation of ATP production, a critical energy source for enzyme secretion and maintenance of electrolyte gradients (41)

However, most existing studies are primarily based on animal models, with limited clinical trial data available

Neuroscience 425, 157168