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In AD, Tau A152T -induced glutamatergic neuron loss is mainly caused by necrosis, which disrupts lysosomal catabolic aspartic protease cathepsin D activity [121]

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Hepatocarcinoma (LOE = B) Liver cancer, most commonly known as hepatocarcinoma, is a common malignancy, and treatment of this cancer with interferon-alpha 2A (IFN- ) has a relatively poor response rate of about 30%