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Description

In their role as primary immune cell of the CNS, they are crucial for maintaining a clean microenvironment by preventing the accumulation of cellular debris and metabolic waste products

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Loss of autophagy in HSCs leads to metabolic stress and altered functionality

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The symptoms associated with this stage reflect uremia , the syndrome in which failing kidneys are no longer able to manage the many biochemical and physiological processes for which they are responsible

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Moreover, excessive autophagy triggered by ER stress is also involved in ferroptosis modulation[163]

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Messina A, Corvaia A, Marino C

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