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Cycle Length and Long-Term Use: Initial assessment cycles typically run 12-16 weeks, which aligns with the duration of clinical trials and allows adequate time to evaluate metabolic response and body composition changes

Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

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