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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

This positive feedback loop further promotes the production of both ROS and miR-21 [125]

Free Radic Biol Med 66:7587 Moore WR, Anderson ME, Meister A, Murata K, Kimura A (1989) Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli : a possible model for mammalian cell protection

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Nature Reviews Drug Discovery, 20(4), 309-325

Pharmaceutical Compositions of Antibodies Antibodies specifically binding a protein of the invention, as well as other molecules identified by the screening assays disclosed herein, can be administered for the treatment of various disorders in the form of pharmaceutical compositions