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Solid tumors, such as osteosarcoma, generally suffer from an inadequate oxygen supply due to the rapid proliferation of cancer cells, incomplete vascularization, and uneven distribution

[DOI] [PMC free article] [PubMed] [Google Scholar] 239.Chao C.L., Weng C.S., Chang N.C., Lin J.S., Kao S.T., Ho F.M

They are abundant in plant-based foods, including fruits, vegetables, cereals, and beverages, and comprise a complex group of over 8000 known compounds ( Based on the number of phenolic rings and structural linkages, they are commonly categorized into five main classes: tannins, lignans, phenolic acids, flavonoids, and stilbenes ( This review highlights the major classes of polyphenols, evaluated as secondary metabolites, along with methods used for their extraction and characterization