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Finally, current challenges and future prospects for advanced applications of MOFs-based biosensors are highlighted

At low micromolar concentrations, inhibition of ALDH2 by 4-HNE is reversible, but at higher concentrations, when the active site thiols are covalently modified, inhibition becomes irreversible (136)

This alone can greatly reduce the appearance of keratosis pilaris, though additional therapies are often necessary for complete clearance in most cases.