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Furthermore, DOX can directly extract Fe 3+ from ferritin (29), suggesting that DOX forms DOX-Fe 3+ complex without free Fe 3+ and that free Fe 2+ and Fe 3+ might not be essential for the formation of DOX-Fe complex and LP production under DOX treatment

doi: 10.3892/etm.2020.8525 63 PalamandaJRKehrerJP

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This finding is consistent with research by Jajoo et al., which demonstrated that miR-21 expression is significantly higher in highly invasive PC-3 M-MM2 cells compared to non-invasive LNCaP cells, suggesting that miR-21 may enhance the invasive capabilities of PCa tumors [116]