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In a 24-week trial in 62 overweight or obese women, 28 with PCOS and 34 without, a reduced-calorie, low-glycemic index diet significantly improved acne, menstrual regularity, and testosterone and SHBG levels

Nature 266:565567 Xu D, Trmulot L, Yang Z, Mhamdi A, Chtel-Innocenti G, Mathieu M, Espinasse C, Van Breusegem F, Vanacker H, Issakidis-Bourguet E, Noctor G (2025) Cytosolic monodehydroascorbate reductase 2 promotes oxidative stress signaling in Arabidopsis