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The injection of tamoxifen and progesterone at E15 to control the timing of NF1 loss led to optic glioma formation at 3 months (82), like those in NF1+/- GFAP CKO mice (77) and BLBPCre

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Statistical analyses Safety set population was defined as all randomized patients who had a baseline evaluation, took at least one study drug, and at least one post-baseline assessment, regardless of study completion or discontinuation

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Data processing: 4-9 EAD provides positional information on glucuronide conjugation sites Zeno DDA data provided excellent MS/MS coverage for TOF MS peaks of interest in both CID and EAD acquisitions