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Note: These benefits have been demonstrated only in controlled research settings (mice or cells)

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An innovative approach to using IGF signalling pathways to target cancer is to use them to direct therapies to the tumour, for example, they can be conjugated to nanoparticles to enhance targeting and penetration of the tumour (Zhou et al., 2015)

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2001 showed ipamorelin at 100 g/kg three times daily subcutaneously for three months counteracted glucocorticoid-induced bone loss in rats, with periosteal bone formation rate increasing 4-fold versus glucocorticoid alone