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placebo on CV outcomes, which showed that dulaglutide was associated with a small yet significant reduction in ED risk (HR 0.92, 95% CI 0.850.99, p = 0.021) in 3725 patients with T2D and class I obesity

[Note 5] So acetate ion (the conjugate base of acetic acid, pK a 4) is perfectly capable of deprotonating water (pK a 14) but the equilibrium will be very unfavorable (a difference of 10 pK a units)

While it still appears to be potentially valuable as a nootropic agent, this detail makes it a less-attractive candidate than some other compounds