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Risks factors for carnitine depletion include age under 24 months, the presence of concomitant neurologic or metabolic disorders, and receipt of multiple AEDs

A total volume of 1 ml was adjusted with sample buffer (10 mM potassium phosphate buffer pH 7.4, 3 mM KCl, 140 mM NaCl, and 6 mM D-glucose)

Furthermore, repeated manic episodes can cause oxidative damage to DNA, interfering with future DNA methylation, hence limiting the possibility of turning certain genes off (66)