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Strangely enough, many of the cases of early-childhood b12 deficiency detail unfavorable reactions

Sigma-Aldrich (Merck)

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If this process is disrupted, a deficiency can occur even with a B12-rich diet

Since high homocysteine levels are often the result of poor conversion of homocysteine to methionine, which is a precursor of SAMe, SAMe depletion and homocysteine accumulation usually go hand-in-hand