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6.4 Conceptual and research implications The framework proposed here is intended to support testable research questions regarding endocrineimmune coordination, rather than to prescribe clinical management or to argue for diagnostic adoption

Biomarker-guided dosing (e.g., TF cysteine redox state, Prx cycling, 8-oxoG with repair indices) helps preserve beneficial transcriptional cues while preventing convergence onto nitrative and Fenton chemistry (Meng et al

Given that studies utilising BNIP3 and BAX/BAK1 have demonstrated that their inhibition or genetic deletion impacts apoptotic and necrotic markers 2,17 , it is reasonable to hypothesise that BNIP3, as a BH3-only protein activator, functions upstream of BAX and/or BAK1

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