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For example, one study of people with diabetic neuropathy found that using both strict blood sugar control and antioxidant supplements improved patient outcomes more than standard care alone

Some studies have synthesized Edaravone derivatives coupled with 1-aminoadamantane with alkylidene or hydroxypropyl groups and investigated their biological activity, and the compounds have been found to inhibit the lipid peroxidation and the calcium-associated mitochondrial permeability, block fast sodium currents in the neurons of central nervous system, and reduce the aggregation of FUS-protein in the typical mutant form of ALS, and have the potential to be optimized for using in the treatment of ALS (29)

We gathered information from studies reporting, in stroke models, that both pharmacological inhibition and genetic deletion of TRPM2 reduced infarct volume, improved behavioral outcomes, and diminished glial reactivity

Immunity 12 , 525?535 (2000)