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The correct strategy is to switch to natural folate forms methylfolate or folinic acid that don't require DHFR, and to reduce EGCG exposure

156 YuL.SunY.ChengL.JinZ.YangY.ZhaiM.et al (2014)

J Control Release 203:4050

We also discuss the metabolic abnormalities leading to hyperhomocysteinemia and the importance of moderate hyperhomocysteinemia in the incidence of cardiovascular pathologies