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O is able to either reduce or oxidize transition metals (e.g., iron, copper) ( destroys the Fe-S clusters of proteins, and the reduced iron undergoes additional redox reactions that cause more injuries, as described below ( Hydrogen peroxide As shown in Reaction 2, Fe(II) returns to the oxidized Fe(III) state, in the process catalyzing the production of H 2 O 2

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Recently, extensive research has indicated that the gut microbiota may play an important role in triggering AITD (Khling et al., 2017), thus providing new ideas for treating AITD