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Many of the diseases related to aging are associated with organic wasting caused by increased longevity, and general deterioration of the functions of the organism that leads to a lower ability to react to changes and preserve homeostasis adaptively (Lpez-Otn et al., 2013)

Two MRL/lpr mice (SLC Japan, Shizuoka, Japan) were independently immunized by an intraperitoneal (i.p.) injection of 100 g of scK2SP(Xa) or tcK2SP(Xa) together with Imject Alum (Thermo Fisher Scientific Inc., Waltham, MA)

The participants were divided into 4 groups, each group comprising 10 subjects

Interestingly, in contrast to growth hormone insensitivity (GHI), the IGF-I deficient animals are neurologically impaired, as was also reported in a single patient with a defect in the IGF-I gene [40]

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